The CAGE instrument used to screen for alcohol abuse, and is often the first instrument used. Based on the CAGE score, the Clinician may then use other instruments (such as the Alcohol Use Disorders Identification Test (AUDIT) instrument) to gather more information about possible alcohol use and abuse. CAGE is not a acronymn, but rather a mnemonic representing the four questions (Cut down, Annoyed, Guilty, Eye-opener). The CAGE instrument is in the public domain, and is based on "Detecting Alcoholism: The CAGE Questionnaire," JAMA 252: 1905-1907, 1984.