Evidence of immunity indicates that a person has plausible evidence that they have already developed immunity to a particular disease. The definition of plausible evidence is a local decision, but best practice would suggest that serological evidence of immunity is the strongest indicator of immunity.

This class contains information regarding the immunological state of the patient with respect to a given disease.

This class represents an evaluation of a given vaccination in which an attempt is made to match the vaccination with a Target Dose Number within a Vaccination Series. If the vaccination event passes the rules for a target dose in a series, the evaluation outcome will contain (a code meaning) "Satisfies", otherwise it will contain (a code meaning) "Does Not Satisfy". "Describes a comparison of an immunization event against published recommendations to determine if the administration is "valid" in relation to those recommendations." - HL7 FHIR, ImmunizationEvaluation

Indicates the eligibility of the Patient to receive a vaccine under a publicly funded vaccine program. See MIROW "IIS collaboration with VFC Program and Grantee Immunization Programs" guidelines.

An entry in a Patient's "Immunization List". This class allows for entries in the list to be associated with the Immunization clinical events in the EHR, and potentially to be de-duplicated if multiple entries are received from different sources.

An Immunization History is the record of a person's immunizations and the attendant information.

"A patient's point-in-time set of recommendations (i.e. forecasting) according to a published schedule with optional supporting justification." - HL7 FHIR, ImmunizationRecommendation

The transmittal of Immunization information to a Immunization Information System (IIS), which are maintained by Public Health Jurisdictions. Note that healthcare providers typically submit all known information regarding the Patient's immunization history to the IIS, not just those vaccinations that they performed themselves. This is in order to ensure that as much information as possible is available to the IIS. The IIS has the burden to de-duplicate records received from multiple providers.

An Immunization Schedule is a series of vaccinations, including the timing of all doses, that is recommended (or compulsory, depending on the disease and the jurisdiction) in order to produce an active immunity to a given disease. Many vaccines require multiple doses for maximum effectiveness, either to produce sufficient initial immune response or to boost response that fades over time. While the term Immunization Schedule often refers to the minimum set of vaccinations a person should have throughout their lifetime, this FHIM class is a set of published rules for evaluating doses of a single vaccine administered and for forecasting the next dose of that vaccine that are due. Note however, that some vaccines, such as the MMR vaccine, targets multiple diseases (Measles, Mumps, and Rubella). Staying with the MMR as an example, the first dose is generally given to children around 9 to 15 months of age, with a second dose at 15 months to 6 years of age, with at least 4 weeks between the doses. The FHIM would then have one instance of ImmunizationSchedule called “MMR”, point to three Indication instances (Measles, Mumps, and Rubella), and point to one VaccineSeries instance where the numberOfDoses property is set to two. The rules (dose 1: age >= 9 months and age <= 15 months; dose2: date>=4 weeks after dose 1 and age: age >=15 months, and age <= 6 years) are in the seriesRule property. "Contains information about the protocol under which the vaccine was administered." - HL7 FHIR, ImmunizationRecommendation.recommendation.protocol

The recommended next dose of a particular vaccine for a given patient. It does not deal with usage projections over a population. This forecast is based on application of the rules of the series dose.

This class contains information regarding the provision of a Vaccine Information Sheet to the patient. A vaccine information document is an educational document intended to outline the risks and benefits of the vaccine. It outlines the impact of infection by the disease causing organism.

Patient Series is an instantiation in time of a Vaccine Series for a given Patient that represents a path towards the goal of protection against a particular disease (e.g., shingles), or a group of diseases that are commonly immunized against together (e.g., measles, mumps, and rubella). It consists of a set of Target Doses. In other words, while the Vaccine Series is the generic plan of doses that all persons sharing certain characteristics should should receive, the Patient Series is the series of doses that a particular Patient has received or is expected to receive.

A statement of a condition that must be met. The evaluation of facts against a rule results in a value of true or false. Rules can be evaluated by humans or by computers; this class is intended to contain rules that are human-readable as well as those that can be evaluated by a rules engine. An example of a Rule would be that the second dose of a vaccine must be administered between six and eight weeks after the first dose.

Each target dose is one step in a patient series. The target dose links the vaccine dose administered to the series dose that it meets the goals of. A vaccine dose may not meet the goals of a given series dose and therefore be not valid.

Information about the administration of a vaccine to a patient. This class is a sub-class of MedicationAdministrationPerformed, and therefore inherits the properties of that class, and then adds vaccination-specific information such as the dose number within a series, and immunity status. "Describes the event of a patient being administered a vaccination or a record of a vaccination as reported by a patient, a clinician or another party and may include vaccine reaction information and what vaccination protocol was followed." - HL7 FHIR, Immunization

This class represents an assertion that an administration of a vaccine to a patient did not occur. Such information is useful when an administration would normally be expected, and this class serves to document that it indeed did not occur (as opposed to leaving the medical record blank). This class may contain (via associations) information regarding why the administration did not occur such as documentation of an Exemption, a Contraindication, or of an established Immunity Status. "Describes the event of a patient being administered a vaccination or a record of a vaccination as reported by a patient, a clinician or another party and may include vaccine reaction information and what vaccination protocol was followed." - HL7 FHIR, Immunization

"A preparation of a weakened or killed pathogen, such as a bacterium or virus, or of a portion of the pathogen's structure that upon administration to an individual stimulates antibody production or cellular immunity against the pathogen but is incapable of causing severe infection." - The American Heritage Medical Dictionary. This class represents a vaccine, identified by a code from a controlled vocabulary.

A vaccine information document is an educational document intended to outline the risks and benefits of the vaccine. It outlines the impact of infection by the disease causing organism. Also known as a Vaccine Information Sheet (VIS).

A series of recommended doses that should be administered according to a set of rules (generally involving the age of the patient or the timing between doses) in order to produce or boost an active immunity to a given disease. "One possible path to achieve presumed immunity against a disease - within the context of an authority." - HL7 FHIR, Immunization.protocolApplied.series

A Series Dose is a specification of how to determine if a particular dose administered meets the goals for that dose in the series.